St. Louis Trauma nurse Casey McDonough thinks her life is interesting enough. Her best friend still drops acid, her ex-husband is a cross-dressing psychiatrist, and her mother has turned the third floor of the family home into the Chapel of Eternal Vigilance. But things begin to go wrong fast when OB/Gyn Dr. Dale Hunsacker arrives on the scene, because Casey suspects that the handsome, charismatic doctor is actually a serial killer. And the only one who takes her seriously, is Hunsacker himself. Caught in a spiral of suspicion and intimidation, Casey works with ex-Marine, ex-Jesuit homicide sergeant Jack Scanlan to help her prove that a monster walks the halls of her hospital.

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On February 20th, trauma nurse Kate Manion has the rare opportunity to see her own hospital from the other side. Badly injured in an auto accident, she lands in her own ICU. She's strapped down, paralyzed and unconscious. And yet, somehow she manages to kill her nurse, the aptly named Attila the Buns.

It's an accident; Kate swears. It isn't an accident when murders keep happening. Someone in the hospital has taken Kate's act as a mandate to kill off the CEOs and supervisors who make life so difficult for a staff struggling to give good patient care in a new world of corporate medicine. But as the corpses pile up, Kate realizes she alone can bring a halt to the work of a serial killer. A serial killer who is acting out the fantasy of every staff member at St. Simon's Hospital. A serial killer who could be one of Kate's closest friends.

With only burned out forensic pathologist B.J. O'Brien for help, Kate has to wade through greed, politics, secrets and suspicion to unearth a murderer she doesn't want to find. And she has to find him—or her—before he strikes too close to home.

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When forensic nurse Timmie Leary-Parker returns home from the street wars of LA to care for her ailing father, she knows that life back in Puckett, Missouri will be a great change for her. She is prepared for the slow pace, the small-town politics and the feeling that everyone knows her business. She even adapts to the mom-and-pop emergency department where she now works. If she can find a safe home for her daughter and treatment for her father’s Alzheimers, she will tolerate almost anything.

That is, until she begins to suspect that a serial killer is walking the halls of her hospital. Patients in the hospital’s Restcrest Alzheimer’s Unit are dying in unprecedented numbers, and old age isn’t answer enough. No one in town wants to investigate. Bad publicity could ruin the town’s most lucrative business, and the primary suspect is its golden-boy director. But Timmie has no choice. Restcrest is the only place that can keep her father safe from his disease. The question is, will it keep him safe from a murderer?

In her search for answers, Timmie turns to burned-out Pulitzer-winning reporter Daniel Murphy, who wants nothing more than peace and quiet. Instead, the two of them find themselves sinking into a morass of corruption and greed that puts at risk all Timmie holds dear.

Trauma nurse and part –time death investigator Molly Burke is having a pretty normal summer night in her St. Louis Emergency Department. And then a well-connected lawyer is wheeled in, victim of a suspected suicide. One suicide is bad. When one suicide grows to four in a matter of days, and all of them are lawyers, the trend stops being an oddity and becomes a real problem. Were the deaths really suicide? Why would a successful, hot young lawyer throw himself from a twentieth floor ledge? And what did the lawyers have in common besides the bar association? It is Molly’s job to find out.

Suddenly, a puzzle becomes a threat. Molly’s investigation unearths secrets the wealthy and powerful don’t want exposed, and Molly is the one who suffers for it. If she doesn’t find the killer soon, she could well be the next victim.

Chris Jackson has secrets. A wildly popular author of suspense novels, she hides away in the tiny town of Pyrite, Missouri, where she resides in an old converted storefront and practices breaking-and-entering on local businesses. The town has adopted her as one of its eccentrics, like Victor and Lester, the town’s resident ventriloquist. And Chris is careful to protect that position. She knows she would never be welcome if the town knew the truth about her past.

Most of the citizens of Pyrite, happy to claim their very own celebrity, don’t think to question her. Brand new police chief Al MacNamara, transplanted from the mean streets of Chicago, isn’t one of them. He hates mysteries, and Chris Jackson is a mystery.

And then, the murders begin. Murders that shatter the little town Chris has come to love. Murders that look suspiciously like those in Chris’s books. Murders that escalate to a grisly stabbing that exactly mimics a story no one could have seen but Chris herself.

Chris can no longer hide. With MacNamara’s help, she is forced to delve into the darkest recesses of her past to expose a murderer, a past that is even darker than the streetwise MacNamara could imagine. Does Chris know the murderer? Is a madman stalking her? Or is Chris right to question her own sanity? Could Chris be committing the murders herself?